IndraLab

Statements

USP25 activates NANOG. 9 / 9
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"USP21 mediated Nanog stabilization is enhanced in mouse ESCs and this stabilization is required to maintain the pluripotential state of the ESCs."
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"Overexpression of USP21 prolonged the protein half-life of Nanog to ~ 2h, whereas the catalytically inactive mutant USP21 C221A had no such effects (XREF_FIG)."
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"KLF15 suppresses stemness of pancreatic cancer by decreasing USP21-mediated Nanog stability."
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"USP21 could significantly enhance the stability of Nanog and then maintain the self-renewal of stem cells."
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"Co-expression of either USP21 isoform significantly prolonged the half-life of Nanog (XREF_FIG)."
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"USP21-mediated Nanog stabilization is required to maintain the pluripotential state of the ESCs [22]."
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"Furthermore, knockdown of USP21 downregulated OCT4, Nanog, Sox2, and ALDH1A1, suppressed the tumor-sphere-forming ability, and reduced the percentage of CD133 cells, whereas overexpression of circCD2AP blocked these inhibiting effects (Figures S1E–S1J)."
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"They further demonstrated that USP21 prevents the degradation of Nanog through deubiquitylation and thus promote maintenance of embryonic stem cells (ESCs)."
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"Depletion of USP21 induces Nanog degradation and mESC differentiation (22)."
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