IndraLab

Statements

USP25 activates NANOG. 5 / 5
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"Co-expression of either USP21 isoform significantly prolonged the half-life of Nanog (XREF_FIG)."
27886188
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"Overexpression of USP21 prolonged the protein half-life of Nanog to ~ 2h, whereas the catalytically inactive mutant USP21 C221A had no such effects (XREF_FIG)."
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"They further demonstrated that USP21 prevents the degradation of Nanog through deubiquitylation and thus promote maintenance of embryonic stem cells (ESCs)."
29263917
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"USP21 mediated Nanog stabilization is enhanced in mouse ESCs and this stabilization is required to maintain the pluripotential state of the ESCs."
29263902
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"USP21 could significantly enhance the stability of Nanog and then maintain the self-renewal of stem cells."
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