IndraLab

"RNA-Seq identified MYBL1-NFIB , NFIB-TBPL1 , and MYBL1-VCPIP1 fusion transcripts, respectively, supporting the diagnosis of AdCC in these three tumors."

"Adenoid cystic carcinoma is characterized by a recurrent t(6;9)(q22–23;p23–24) translocation that results in a MYB-NFIB fusion gene. xref , xref An alternative MYBL1-NFIB gene fusion has been reported in a subset of cases. xref , xref , xref Various other genes have been reported to substitute for MYB , MYBL1 and NFIB , including TGFRB3, RAD51B, YTHDF3, AIG1, XRCC4 and PTPRD , amongst others. xref , xref , xref – xref In our cohort of 20 AdCCs, the MYB-NFIB fusion was identified in 60% and the MYBL1-NFIB fusion in 25%, while two cases harbored novel NFIB-TBPL1 and MYBL1-VCPIP1 fusions products."

"MYB was rearranged in 60% (12/20), MYBL1 in 30% (6/20) and NFIB in 5% (1/20); two tumors exhibited novel fusion products, including NFIB-TBPL1 and MYBL1-VCPIP1 ."

"In addition, two cases were found to harbor novel fusion genes ( NFIB-TBPL1 and MYBL1-VCPIP1 )."