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HDX activates USP3. 1 / 1

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"In the USP5 structure, there is a close π-stacking interaction between the pyridine moieties of ZQ1 and Y259, which is analogous to the HDX-supported 59/USP3 Y94 interaction discussed above.Compound 59 binds USP3 with a K of around 14 μM, which would not be sufficient for a traditional occupancy-based competitor."

38222562

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IndraLab

Statements

HDX activates USP3. 1 / 1

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