IndraLab

Statements

USP1 increases the amount of KDM4A. 5 / 5
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"USP1 knockdown in RV1, LNCAP, and PC3 cells significantly decreased KDM4A protein level, but did not affect KDM4A mRNA level."
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"We previously found that USP1 knockdown decreased levels of KDM4A in PC cells."
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"As shown in Figure XREF_FIG, USP1 knockdown dramatically reduced levels of KDM4A and c-Myc, whereas the reconstitution of KDM4A was able to efficiently rescue their expression."
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"USP1 can promote the growth and tumorigenesis of PCa cells by stabilizing the expression of KDM4A (Cui et al., 2020)."
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"Similarly, USP1 knockdown in RV1 cells using 2 specific shRNAs significantly decreased KDM4A protein levels and increased cellular sensitivity to enzalutamide treatment, whereas overexpression of KDM4A in depleted cells with USP1 reversed hypersensitivity to enzalutamide treatment."
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