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CTNNB1 leads to the phosphorylation of CTNNB1 on Y142. 3 / 3
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"Further validation showed that after downregulating the expression of VEGFR1 isoform5 in HUVECs with siRNA targeting VEGFR1 isoform5 without affecting the expression of other isoforms (Fig. S9G), the phosphorylation level of β-catenin Y142 decreased under AGEs exposure (Fig. 7I), while after overexpressing VEGFR1-isoform5 protein, the β-catenin Y142 phosphorylation level increased (Fig. 7J), leading us to infer that VEGFR1 isoform5 mediates β-catenin Y142 phosphorylation."
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"Finally, we demonstrated that pharmacological FAK inhibition attenuated β-catenin Y142 phosphorylation, confirming that FAK was required for HMGB1-mediated β-catenin Y142 phosphorylation.Moreover, Wnt[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"To address the possibility that phosphorylation of β-catenin at Y142 modulates the extent to which MET and β-catenin functionally interact, neocortical neurons were transfected with wild-type β-catenin that can be phosphorylated at Y142 with HGF treatment ( xref ) or a mutant form of β-catenin that cannot be phosphorylated at Y142 (β-cateninY142F; xref )."
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