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Spautin-1 inhibits USP13. 7 / 7
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"It has been reported that spautin-1 suppresses autophagy via inhibition of USP10 and USP13, the two deubiquitinases to degrade PIK3C3/VPS34 and BECN1 [12]."
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"To directly test if spautin-1 can inhibit the deubiquitinating activity of USP10 and USP13, we tested the activity of isolated USP10 and USP13 on ubiquitinated Beclin1 in vitro."
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"Using this assay, we found that spautin-1 inhibited USP10 and USP13 with IC 50 of ~ 0.6-0.7 microM while having no inhibitory activity toward CYLD which is also a member of ubiquitin specific peptidase family (XREF_FIG)."
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"Further, inhibition of USP13 by spautin-1 caused a decrease in TXNIP levels in MLE12 cells (Fig. 4)."
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"Consistently, knockdown or pharmacological inhibition of USP13 by spautin-1 retards the growth, differentiation and invasion of many tumors, providing a possibility for antagonizing the drug resistance of tumor cells."
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"Another autophagy inhibitor, spautin-1, degrades class III PI3K by inhibiting the activity of the ubiquitin specific peptidases, USP10 and USP13 (Mateo et al., 2013, Liu et al., 2011)."
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"Among them, spautin-1, a well-established autophagy inhibitor, is known to promote the degradation of BECN1 and PIK3C3/VPS34 by targeting the ubiquitin-specific peptidases, USP10 and USP13 [12]."
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