IndraLab

Statements

OTUB1 binds ESRRA. 14 / 14
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"Finally, our study confirmed that AIL reduced ERRα protein level by inhibiting the catalytic activity of OTUB1 and disrupting the interaction between OTUB1 and ERRα, which resulted in the ubiquitin-mediated degradation of ERRα."
39864589
sparser
"AIL was found to inhibit the enzyme activity of OTUB1 by interacting with the C91 residue and disrupt the interaction between OTUB1 and ERRα, ultimately leading to the inhibition of ERRα."
39864589
sparser
"Our research identified a novel protein–protein interaction between OTUB1 and ERRα, revealing their role in modulating breast cancer proliferation and tumorigenesis."
39864589
sparser
"Our data show that OTUB1 is a novel target of ERRα and indicate that ERRα-OTUB1 signaling may play a significant role in CRC metastasis."
31737118
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"We assumed that there could be a direct interaction between OTUB1 and ERRα."
39864589
sparser
"Our study revealed that OTUB1 binds to ERRα and enhances its protein stability."
39864589
sparser
"The research elucidates the influence of AIL on the ubiquitin–proteasome pathway by examining its effects on the deubiquitinating enzyme activity of OTUB1, as well as the protein interactions between OTUB1 and ERRα."
39864589
sparser
"The results showed that exogenously overexpressed Flag-tagged OTUB1 interacted with endogenous ERRα as well as the exogenously overexpressed HA-tagged ERRα ( xref A-C)."
39864589
sparser
"Ailanthone (AIL) inhibits the enzyme activity of OTUB1 by interacting with the C91 residue and disrupts the interaction between OTUB1 and ERRα, ultimately leading to the inhibition of ERRα."
39864589
sparser
"AIL inhibits the deubiquitylation activity of OTUB1, obstructs the binding of OTUB1 and ERRα, and increases the ubiquitylation level of ERRα."
39864589
sparser
"In summary, our results indicate a direct interaction between OTUB1 and ERRα."
39864589
sparser
"OTUB1 interacts with ERRα and enhances ERRα protein stability."
39864589
sparser
"Collectively, our data demonstrated that AIL directly inhibited OTUB1 catalytic activity and blocked the interaction between OTUB1 and ERRα."
39864589
sparser
"To further demonstrate that ERRα binds to the OTUB1 promoter through ERRE-S4, we conducted ChIP assays in HCT116 cells and used primers amplifying the +670/+901 region of OTUB1 promoter, containing ERRE-S4 (Figure xref A)."
31737118