IndraLab

Statements

USP29 activates SARS-CoV-2. 5 / 5
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"For example, aberrant USP29 deubiquitylation could enhance the virulence of SARS-CoV-2 by preventing proteasome degradation of ORF9b (34)."
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"The Deubiquitinase USP29 Promotes SARS-CoV-2 Virulence by Preventing Proteasome Degradation of ORF9b."
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"34 However, previous studies have reported that Usp29 can enhance SARS-CoV-2 virulence by preventing the proteasomal degradation of ORF9b, and the level of the USP29 mRNA in the peripheral blood mononuclear cells of SARS-CoV-2 patients was higher than that in healthy individuals.35 Interestingly, the change in the USP mRNA levels in human peripheral blood mononuclear cells did not correspond with those in the USP protein levels in the mouse cerebral cortexes."
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"Moreover, USP29 promoted the virulence of VSV-eGFP and transcription and replication-competent SARS-CoV-2 virus-like particles (trVLP) by enhancing ORF9b-mediated inhibition of IFN induction and NF-κB activation."
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"USP29 increases the virulence of VSV-eGFP and SARS-CoV-2 trVLP.."
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