IndraLab

Statements

Stattic inhibits STAT1. 7 / 7
| 7
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"STATTIC has a high potency at 37degreesC and does not significantly inhibit other dimeric transcription factors such as c-myc and Max, Jun and Jun, and STAT1 or other important signaling molecules such as Src, JAK1, JAK2, Akt, JNK, and ERK1/2."
25398767
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"Because Stattic was initially shown to selectively inhibit STAT3, but not the related factors STAT1 and STAT5, Stattic has enjoyed popularity as a " specific " STAT3 inhibitor in mechanistic investigations of STAT3."
| PMC
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"Noteworthy, in the original article showing Stattic specificity, Stattic inhibited STAT1 at 40% with an IC50 of 10 μM at 30 °C."
31022374
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"Furthermore, we intravitreally injected Stattic, which inhibits both STAT1 and STAT3 activation 56 at 1 hour after the induction of TON."
27960090
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"Fludarabine and stattic inhibited STAT1 or STAT3 activation, respectively, in a dose-dependent manner (Supplementary Fig. 2c, d); however, these inhibitors failed to rescue IFNγ imposed differentiation inhibition (Supplementary Fig. 2e, f)."
36045134
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"Sanseverino et al. found that STATTIC inhibits not only STAT3 activation but also that of STAT1 and to a lesser extent of STAT2, in response to cell activation by IL-6 or IFNbeta based on studies using human monocyte derived dendritic cells."
30283459
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"These findings suggest that Stattic may directly attenuate the STAT1 siRNA effect on E-cadherin expression."
24274066