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UCHL3 activates Ku80 chromatin binding. 4 / 4
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"To gain insight into how UCHL3 contributes to Ku80 chromatin binding after DSB induction , firstly , we examined the effect of UCHL3 on the DNA-binding activity of Ku by electrophoretic mobility shift assay with purified these proteins ( Fig. 5A-C ) ."
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"Since it was reported that Ku ubiquitylation is a prerequisite for Ku removal from chromatin , we hypothesized that UCHL3 may enhance Ku80 chromatin binding by antagonizing Ku80 ubiquitylation ."
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"UCHL3 enhances Ku80 chromatin binding and directly deubiquitylates Ku80 To examine the effect of UCHL3 on Ku regulation , we investigated IR-induced foci ( IRIF ) formation of Ku80 , which indicates loading of Ku onto DSB sites ."
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"UCHL3 enhances Ku80 chromatin binding upon DSB induction ."
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