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This Service

A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

Modified mutated CYLD inhibits cell differentiation. 2 / 2

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"Overexpression of non SUMOylatable mutant CYLD in neuroblastoma cells reduced retinoic acid induced NF-kappaB activation and differentiation of cells, but instead promoted cell death."

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"By contrast, the expression of a mutant CYLD C/S that inhibits the endogenous CYLD deubiquitination function impairs keratinocyte differentiation."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...