IndraLab
Statements
"We demonstrate that TRAF6 ubiquitinates the proform of AEP through K63-linked polyubiquitin, reversible by USP17, and forms a complex with HSP90α to subsequently promote pro-AEP intracellular stability as well as secretion. We now present evidence that AEP is a substrate for TRAF6 ubiquitination, resulting in AEP/TRAF6/HSP90α complex formation."
"We demonstrate that TRAF6 ubiquitinates the proform of <span class="match term1">AEP</span> through K63-linked polyubiquitin, reversible by <span class="match term0">USP17</span>, and forms a complex with HSP90alpha to subsequently promote pro-<span class="match term1">AEP</span> intracellular stability as well as secretion."