IndraLab

Statements

USP22 deubiquitinates CD274. 13 / 17
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"However, our previous study demonstrated that USP22 induces the deubiquitination of PD-L1 and prevents PD-L1 degradation."
32850399
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"Deubiquitinase USP22 deubiquitinates PD-L1, preventing its proteasomal degradation (151)."
38426097
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"USP22 deubiquitinated PD-L1 and inhibited its proteasome degradation."
32665011
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"Among them, USP9X, CSN5, USP22 and USP7 are responsible for the deubiquitination and stabilization of PD-L1 in tumor cells [98–101]."
36998063
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"Huang et al. reported that USP22 deubiquitinated PD-L1 and maintained its stabilization, leading to inhibition of anticancer immunity."
38638430
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"In HCC, USP22 impaired anticancer immunity by deubiquitinating CD274 44 and enhanced hypoxia-induced stemness via HIF-1α deubiquitination."
36528490
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"In addition, USP22 could inhibit the ubiquitination of PD-L1 protein."
35583065
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"In addition, USP22 deubiquitinated CD274 leading to the stabilization of its expression, knockdown of USP22 enhanced the anticancer immunity of CD274 in liver cancer [ 31 ]."
38176298
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"Contrary, it is reported that PD-L1 can be deubiquitinated by CSN5, USP22, USP7, USP9X, and OTUB1 (Feng et al.)."
37822939
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"USP22 deubiquitinates CD274 to suppress anti-cancer immunity."
31399419
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"USP22 can deubiquitinate PD-L1 itself or CSN5 for their stabilization [233] (Figure 3)."
| PMC
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"These exosomes can affect T cells by decreasing miR-30a-5p levels, targeting ubiquitin-specific peptidase 22 (USP22), a deubiquitinating enzyme that can deubiquitinate PD-L1 and increase its stability."
36612180
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"USP22 deubiquitinates CD274 to suppress anticancer immunity [13]."
36906615