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"In addition, USP22 could inhibit the ubiquitination of PD-L1 protein."

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"USP22 deubiquitinated PD-L1 and inhibited its proteasome degradation."

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"USP22 deubiquitinates CD274 to suppress anti-cancer immunity."

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"However, our previous study demonstrated that USP22 induces the deubiquitination of PD-L1 and prevents PD-L1 degradation."

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"USP22 can deubiquitinate PD-L1 itself or CSN5 for their stabilization [233] (Figure 3)."

| PMC

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"Here, we identified ubiquitin-specific protease 22 (USP22) as a novel deubiquitinase of CD274."

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