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Statements

USP7 activates CD274. 8 / 8
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"3.6 Inhibition of USP7 decreased PD-L1 expression invivo."
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"Inhibition of USP7 decreased PD-L1 expression in vivo The results from in vitro analysis prompted us to make a hypothesis that knockdown of USP7 can affect mPD-L1 expression in vivo , we assessed the ability of USP7-depleted cells to impair tumor growth in BALB / c mice bearing MFC Con and USP7 KD cells ."
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"As USP7 abrogation can decrease the expression of PD-L1 without impacting on its mRNA level , and PD-L1 was reported to be ubiquitinated and subjected to proteasome mediated degradation33 ,39 , whether USP7 erases the ubiquitination of PD-L1 needs to be answered ."
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"Abrogation of USP7 downregulated PD-L1 expression by increasing PD-L1 polyubiquitination ."
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"Moreover , USP7 can promote the amount of PD-L1 in a dose-dependent manner ( Fig. 3D ) ."
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"As PD-L1 on membrane of cancer cells exhibits immunosuppressive effect through binding to PD-1 on activated T cells XREF_BIBR, whether USP7 positively regulates membrane PD-L1 remains unclear."
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"Collectively , our findings indicate that in addition to inhibiting cancer cells proliferation , USP7 inhibitor can also downregulate PD-L1 expression to enhance anti-tumor immune response simultaneously ."
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"These results demonstrate that abrogation of USP7 can attenuate the PD-L1 / PD-1 interaction and sensitize gastric cancer cells to T cell killing ."
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