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NLRP3 bound to NEK7 activates BRCC3. 1 / 1

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"In the model, both Ser806 and Tyr861 must be unphosphorylated for NLRP3 to bind NEK7, and NLRP3 must bind NEK7 to allow BRCC36 mediated deubiquitylation of the LRR domain.The phosphorylation of Ser295 has been shown to act as both a positive and negative regulator of NLRP3 activation ( Figure 6 )."

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IndraLab

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NLRP3 bound to NEK7 activates BRCC3. 1 / 1

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