IndraLab

Statements

TP53 decreases the amount of USP7. 3 / 3
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"Under insufficient glucose availability, the level of USP7 is inhibited by p53, resulting in degradation of PRMT1 via ubiquitination of the proteasome pathway, thereby inhibiting the Warburg effect and proliferation of NSCLC cells."
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"However, activation of p53 mediates protein degradation of PRMT1 through inhibiting the level of USP7 under glucose insufficiency."
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"Additionally, the expressions of p53 and p21 could be promoted by the overexpression of USP7, which was reversed by the downregulation of p53 ( Figure 4G,H)."
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