IndraLab

Statements

BAP1 inhibits BAP1. 11 / 13
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"BAP1-inactivated melanocytoma is associated with BRAF or NRAS and BRCA1-associated protein 1 (BAP1) mutations."
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"Tumors with both miR-31 and BAP1 overexpression exhibited significantly higher levels of BAP1 compared to tumors with miR-31 overexpression, suggesting that BAP1 overexpression could rescue the BAP1 suppression caused by miR-31."
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"There were no chromosomal losses in either the Bap1 or Nf2 regions."
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"Overexpression of wild-type BAP1 reversed the sensitivity of BAP1 knockout cells to RITA, while overexpression of the mutant BAP1 (C91S) with inactivated ubiquitinase did not produce any rescue effect."
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"Ubiquitylation of BAP1 near its nuclear localization sequence negatively regulates its activity by excluding BAP1 from the nucleus, where most of its targets reside [84] ."
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"BAP1-inactivated melanocytic tumours (BIMTs) occur sporadically and in association with a familial tumour predisposition syndrome involving germline mutations in the BRCA1-associated protein-1 (BAP1) gene."
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"Furthermore, although CDKN2A/p16 homozygous deletion was not confirmed by FISH, there was loss of BAP-1 based on IHC (Fig. 2G)."
36420072
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"Although there was no loss of MTAP based on IHC and homozygous deletion of CDKN2A/p16 based on FISH (Fig. 5E and F), there was loss of BAP-1 based on IHC (Fig. 5D)."
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"In these haplo-insufficient cells (designated as HAP1 BAP1 KO), there was a complete loss of BAP1 compared with the parental HAP1 WT cells."
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"To further investigate whether BAP1 overexpression induced the opposite effect of BAP1 depletion on MSC migration, we performed wound healing, transwell migration, and invasion assays under BAP1 overexpression conditions."
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"A loss of BAP1 (BRCA1-associated protein-1) expression, measured by immunohistochemistry, was also associated with this phenotype (r = −0.38 and q value = 4.61 × 10 ; Supplementary Fig. 19)."
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