IndraLab

Statements

Azithromycin inhibits NLRP3. 9 / 9
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"Our studies are unique in that NLRP3 mRNA expression is decreased in LPS stimulated monocytes treated with azithromycin."
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"To determine if azithromycin reduces NALP3 protein at the pre-translational level, we assayed levels of its coding NLRP3 mRNA."
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"In vitro, azithromycin and erythromycin inhibited NLRC4 and NLRP3 inflammasomes activation."
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"Azithromycin decreases NALP3 mRNA stability in monocytes to limit inflammasome dependent inflammation."
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"Finally, there is evidence to suggest that azithromycin inhibits the activity of the NLRP3 inflammasome and the subsequent release of IL-1beta and IL-18 [259,293]."
| PMC
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"Azithromycin decreases NLRP3 mRNA by decreasing transcript stability."
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"Azithromycin increases NLRP3 mRNA degradation without altering NLRP3 promoter activity."
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"These data further support that azithromycin decreases NLRP3 mRNA stability; however, the inability of the antibiotic to totally abrogate NLRP3 mRNA 3 ' UTR activity in response to LPS may be related to the experimental conditions used or other regulatory response elements that are not contained within the fragment tested."
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"In assessing the kinetics for these anti-inflammatory effects of azithromycin, the compound decreased NALP3 expression in unstimulated THP-1 cells treated with azithromycin by 4-6h and LPS modestly increased NALP3 mass by 4-8h (Figs."
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