IndraLab

Statements

USP22 is ubiquitinated. 11 / 11
| 11
sparser
"Fourth, USP22 is ubiquitinated and degraded by CDC20-containing APC/C complex during cell exit from M phase, presumably to release the brake on CCNB1 degradation."
27030811
sparser
"Besides, USP22 could remove poly-ubiquitin chain of CSN5, while CSN5 seemed no effect on USP22 ubiquitination (Fig. xref c, Fig. xref d)."
32665011
sparser
"Stimulation with EPI markedly reduced USP22 ubiquitination levels ( xref ), supporting our speculation that EPI protects USP22 from ubiquitination-mediated degradation."
39151008
sparser
"Lastly, ubiquitylation of USP22 mediated by the anaphase promoter complex/cyclosome (APC/C) induces USP22 protein degradation during the cell cycle [ xref ]."
27057639
sparser
"Our data suggest that ATK-mediated phosphorylation of USP22 is critical for its stabilization because mutation of the phosphorylation residues increased USP22 ubiquitination and facilitated its proteasomal degradation."
39151008
sparser
"Among these differentially ubiquitylated USP22 targets numerous DNA repair proteins, including XPC and RAD23B, were identified."
31740444
sparser
"Conversely, treatment with the AKT-specific inhibitor facilitated USP22 protein degradation ( xref ), increased the USP22 ubiquitination ( xref ), and inhibited the AKT and USP22 interaction in breast cancer cells ( xref )."
39151008
sparser
"Interestingly, we also observed Morusin caused conformational changes in the active pocket residues 255–262 after MD-50 ns, indicating that Morusin may inhibit USP22 ubiquitination activity through al[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
37769523
sparser
"Loss of AKT-mediated phosphorylation markedly increased USP22 ubiquitination and abolished EPI-induced inhibitory efficacy ( xref )."
39151008
sparser
"However, of those four DUBs, only USP22 substantially decreased KDM1A ubiquitination ( xref )."
27501329
sparser
"Treatment with topotecan had no significant effect on USP22 mRNA levels (Figure xref ), but facilitated the ubiquitination of USP22 (Figure  xref )."
39135915