IndraLab

Statements

Imatinib inhibits KCNH2. 3 / 3
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"Furthermore, imatinib markedly reduced hERG currents in HEK293T-hERG cells, this effect was accompanied by inhibition of CML cell proliferation and apoptosis, as well as suppression of vascular endothelial growth factor (VEGF) secretion."
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"According to the formal studies, imatinib could preferentially block the open HERG channel, contributing to QT interval prolongation [XREF_BIBR]."
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"The results demonstrated that hERG1 was highly detected in K562 cells and primary CML cells, and down-regulated by imatinib at mRNA and protein levels."
22161019