IndraLab

Statements

EZH2 decreases the amount of USP22. 7 / 7
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"Consequently, EZH2 suppresses the expression of ubiquitin-specific peptidase 22 (USP22) by modifying H3K27me3, leading to enhanced OS, inflammation, and apoptosis in rat cardiomyocytes [52]."
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"The results indicate that EZH2 inhibition can upregulate USP22 and PD‐L1 expression in four of five primary cells (Figure 7D,E)."
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"Inhibition of ubiquitin-specific peptidase 22 (USP22) expression by EZH2 through H3K27me3 modification aggravates cardiac injury in SIMD rats 30."
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"EZH2 repressed ubiquitin-specific peptidase 22 (USP22) expression through H3K27me3 modification."
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"EZH2 inhibition transcriptionally upregulates USP22 expression, and upregulated USP22 further stabilizes PD-L1."
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"By contrast, the deubiquitinating enzyme USP22 promotes PD-L1 stabilization in colon cancer (COAD), while EZH2 inhibits USP22 transcription via H3K27me3, leading to PD-L1 degradation [165]."
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"Overexpression of EZH2 could modestly inhibit the transcription of USP22 and compensate for the increased USP22 expression resulting from EZH2 knockdown (Figure 3F,G)."
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