IndraLab

Statements


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"In parallel, CoQ10 inhibits NLRP3 inflammasome activation and systemic inflammatory response after burn injury."

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"In this study , NLRP3 was significantly suppressed by CoQ10 while Foxp3 exhibited increased expression in liver ."

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"Taken together, our study discovered that CoQ10 can suppress NLRP3 activity in KCs and improves Foxp3 + Tregs differentiation depending on M2 macrophage polarization of KCs to ameliorate hepatic IRI."

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"In a 2018 study, Chokchaiwong and colleagues investigate the ability of CoQ10 to restore mitochondrial function, and to prevent oxidative damages and NLRP3 activation in multiple acyl-CoA dehydrogenase deficiency (MADD), an autosomal recessive disorder that causes mitochondrial dysfunction [96]."

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"Coenzyme Q10 serves to couple mitochondrial oxidative phosphorylation and fatty acid beta oxidation, and attenuates NLRP3 inflammasome activation."

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"These data indicate that CoQ10 mitigates mitochondrial dysfunction and thereby inhibits NLRP3 inflammasome activation and systemic inflammatory response after burn injury."

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"In this study, NLRP3 was significantly suppressed by CoQ10 while Foxp3 exhibited increased expression in liver."