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Coenzyme Q10 inhibits NLRP3. 11 / 11
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"In a 2018 study, Chokchaiwong and colleagues investigate the ability of CoQ10 to restore mitochondrial function, and to prevent oxidative damages and NLRP3 activation in multiple acyl-CoA dehydrogenase deficiency (MADD), an autosomal recessive disorder that causes mitochondrial dysfunction [96]."
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"In this study , NLRP3 was significantly suppressed by CoQ10 while Foxp3 exhibited increased expression in liver ."
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"These results suggested that CoQ10 upregulated Tregs infiltration through suppressing NLRP3 inflammatory signals in mice after I/R.As an antioxidant, CoQ10 is located within the inner mitochondrial me[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Taken together, these results demonstrated that CoQ10 might suppress the activation of NLRP3/IL1β signaling by inhibiting excessive ROS production.As previously reported, IL1β is synthesized in an inactive form (pro-IL1β), and its secretion requires NLRP3-mediated cleavage, while the activation of the NLRP3 inflammasome requires a typical two-step stimulation [55, 56]."
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"Importantly, our western blot analysis confirmed that CoQ10 treatment significantly inhibited the activation of the NLRP3 inflammasome, resulting in attenuated synthesis and secretion of IL1β."
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"Conversely, supplementation with CoQ10 enhances mitochondrial function, reduces excessive lipid peroxidation, and ultimately inhibits the formation of NLRP3 inflammasomes and cell death in ETFDH-mutated lymphoblastoid cells [66]."
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"These data indicate that CoQ10 mitigates mitochondrial dysfunction and thereby inhibits NLRP3 inflammasome activation and systemic inflammatory response after burn injury."
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"CoQ10-treated macrophages exhibit a less inflammatory state and suppressed activation of the NLRP3/IL1beta pathway."
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"In parallel, CoQ10 inhibits NLRP3 inflammasome activation and systemic inflammatory response after burn injury."
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"Overall, these results support the hypothesis that CoQ10 inhibits the activation of the NLRP3/IL1β pathway in macrophages."
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"Coenzyme Q10 serves to couple mitochondrial oxidative phosphorylation and fatty acid beta oxidation, and attenuates NLRP3 inflammasome activation."
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