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USP19 increases the amount of α-synuclein. 5 / 5
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"Our finding that USP19 promotes α-synuclein secretion not only suggests a physiological link between MAPS and protein-misfolding disease, but also provides a potential target for therapeutic intervention in α-synuclein propagation and α-synucleinopathies."
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"Notably, α-synuclein secretion promoted by either USP19 or DNAJC5 is mostly soluble."
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"To investigate whether MAPS is involved in cell-to-cell transmission of misfolded proteins observed in neurodegenerative diseases , we tested whether USP19 promotes the secretion of α-synuclein, a natively unfolded cytosolic protein known to be released from cells through exosomes as well as an undefined mechanism ."
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"Interestingly, WT USP19 but not USP19 or USP19 significantly stimulated α-synuclein secretion (Fig. 2h)."
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"Recently, a novel, unconventional mechanism underlying the cellular secretion of α-synuclein mediated by the ubiquitin-specific protease 19 (USP19) was identified."
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