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USP8 activates CTNNB1. 7 / 7
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"Thus, our study demonstrated that USP8 activated the Wnt/beta-catenin signaling through a post-translational mechanism of beta-catenin."
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"USP8 depletion inhibits Wnt/beta-catenin signaling pathway activity."
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"Consistently, the decrease of β-catenin induced by USP8 depletion could be reversed by overexpression wild-type (WT) USP8, but not its catalytically inactive mutant (USP8-C786A) (Fig. 3G, H)."
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"USP8 and UBPY is reported to activate the Wnt and beta-catenin pathway by targeting Frizzled G protein coupled protein XREF_BIBR."
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"Deletion of USP8 markedly reduced the protein abundance of β-catenin, and the reduced β-catenin protein abundance could be restored by ectopic expression of USP8-WT, but not its catalytically inactive mutant USP8 ."
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"Our results suggested that USP8 promotes tumor progression by regulating β-catenin."
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"Thus, our study demonstrated that USP8 activated the Wnt/beta-catenin signaling through a post-translational mechanism of β-catenin."
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