IndraLab

Statements

EF-hand binds SCN5A. 2 / 2
| 2
sparser
"Wingo et al. ( xref ) proposed a novel mechanism for modulation of Na channel function where Ca ions bind directly to hH1 via an EF-hand motif in the C-terminal domain."
19333131
sparser
"Although the structure has the overall architecture of a paired EF-hand domain, the NaV1.2 C-terminal domain does not bind Ca2+ through the canonical EF-hand loops, as evidenced by monitoring 1H,15N chemical shifts during aCa2+ titration."
19129176