IndraLab

Statements

USP14 inhibits HTT. 3 / 3
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"USP14 inhibition activates the proteasome, removes tau oligomers, and promotes huntingtin aggregation [19], suggesting that it contributes to aggregate deposition in neurodegenerative diseases."
38780644
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"Despite these promising effects on AD pathology, USP14 inhibition may accelerate HD pathology since this DUB is associated with improved HTT clearance (Figure 2)."
36926679
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"Over-expression of USP14 reduces polyQ huntingtin aggregation and protects against cell degeneration by inhibiting IRE1alpha phosphorylation and blocking ER stress in PC6.3 cells."
28381987