IndraLab

Statements

TESPA1 binds COPS6. 4 / 4
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"Tespa1 interacts with CSN6 to inhibit c-Myc degradation in HSCs."
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"Given that CSN6 is a potential Tespa1 interacting factor by protein-protein interaction analysis using STRING database (Supplementary Fig.  xref ), we first conducted an in situ proximity ligation assay and found that Tespa1 could interact with CSN6 in HSCs upon 5-FU and IR treatment (Supplementary Fig.  xref )."
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"These data illustrate that Tespa1 can interact with CSN6 to inhibit c-Myc degradation in HSCs during hematopoietic stresses."
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"Accordingly, it is reasonable to propose that Tespa1 can interact with CSN6 to inhibit c-Myc degradation in HSCs."
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