IndraLab

Statements

UCHL3 activates Neoplasm Invasiveness. 6 / 6
| 6
reach
"Our findings showed that knockdown of UCHL3 inhibited cell growth, migration and invasion in cervical cancer cells while UCHL3 knockdown inhibited cervical cancer development and metastasis in vivo in mouse models."
36527747
reach
"Moreover, a soft agar colony formation assay showed a similar result: stable UCHL3 overexpression, but not UCHL3 expression, notably increased the EJ cell invasion rate (Fig. 1C)."
37740194
reach
"UCHL3 induced the growth, invasion, and malignancy of CRC cells."
37580737
reach
"Finally, UCHL3 deubiquitinate and stabilize the proliferation-associated transcription factor FOXM1 and promote the invasiveness of pancreatic cancer cells [169]."
35884607
reach
"Therefore, UCHL3 increased EJ cell proliferation, viability, migration and invasion, and these effects depended on its deubiquitinating activity."
37740194
reach
"Therefore, the biological function of UCHL5 requires more investigation.One recent study reported that UCHL3 promotes GC cell migration and invasion by upregulating IGF2 [85]."
36497313