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PRMT5 methylates SMAD3. 4 / 4
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"We also confirmed that PRMT5 interacted with Smad3 in TGF-β-stimulated cardiac fibroblasts using IP-WB analysis (Fig.  xref ) and found that Smad3 was not methylated by PRMT5 in vitro (Supplementary Fig.  xref )."
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"We also confirmed that PRMT5 interacted with Smad3 in TGF-β-stimulated cardiac fibroblasts using IP-WB analysis (Fig. 3e) and found that Smad3 was not methylated by PRMT5 in vitro (Supplementary Fig. 12)."
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"This finding naturally raises the question of whether PRMT5 also directly methylates and thereby activates Smad3, but we have shown that this is not the case, as the in vitro methylation assay carried out in this study revealed that Smad3 was not methylated by PRMT5."
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"This finding naturally raises the question of whether PRMT5 also directly methylates and thereby activates Smad3, but we have shown that this is not the case, as the in vitro methylation assay carried out in this study revealed that Smad3 was not methylated by PRMT5."
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