IndraLab

Statements

UCHL1 decreases the amount of MDM2. 2 / 2
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"We further found that UCHL1 induced p53 accumulation and reduced MDM2 protein level, and subsequently upregulated the expression of p21, as well as cleavage of caspase3 and PARP, but not in catalytic mutant UCHL1 C90S expressed cells."
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"Thus, in breast cancer models, UCHL1 can induce the levels of p53 and reduce mdm2 protein levels."
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