IndraLab

Statements

SIRT1 activates mutated ATXN3. 2 / 2

| 2

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reach

"Therefore, we hypothesized that SIRT1 increases mutant ataxin-3 clearance by activating autophagy."

27165717

➶

reach

"This study indicates that in fact SIRT1 plays an important role in ataxin-3 clearance through the participation on autophagy, because the reduction of mutant ataxin-3 promoted by SIRT1 is reverted when ATG5 is genetically silenced."

27165717

INDRA sources:

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IndraLab

Statements

SIRT1 activates mutated ATXN3. 2 / 2

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