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This Service

A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

SIRT1 activates mutated ATXN3. 2 / 2

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"Therefore, we hypothesized that SIRT1 increases mutant ataxin-3 clearance by activating autophagy."

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reach

"This study indicates that in fact SIRT1 plays an important role in ataxin-3 clearance through the participation on autophagy, because the reduction of mutant ataxin-3 promoted by SIRT1 is reverted when ATG5 is genetically silenced."

27165717

Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...