IndraLab

Statements

USP12 activates Notch. 2 / 2

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"Specifically silencing USP12 impedes the transport of Notch to lysosomes, resulting in an increase in cell surface receptors and heightened Notch activity."

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"The Ubiquitin specific Protease 12 (USP12) is a negative regulator of Notch signaling as USP12 directly targets Notch and directs it to lysosomal degradation."

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INDRA sources:

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IndraLab

Statements

USP12 activates Notch. 2 / 2

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