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USP10 deubiquitinates SIRT6. 21 / 22
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"Second, USP10 suppresses SIRT6 ubiquitination and protects SIRT6 from proteasome mediated degradation."
24332849
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"As previously mentioned, the peptidase USP10 de-ubiquitinates SIRT6, thereby protecting it from proteasomal degradation."
| PMC
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"To confirm that USP10 mediates SIRT6 deubiquitination, SIRT6-Myc was immunoprecipitated in USP10-expressing cells."
37023208
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"The results revealed that USP10 negatively regulated SIRT6 ubiquitination (Fig 4L)."
37023208
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"Lin et al. showed that USP10 inhibits the occurrence and development of colon cancer by deubiquitinating SIRT6."
37184153
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"Moreover, we found that USP10 (ubiquitin-specific protease 10) can interact with SIRT6 to deubiquitinate SIRT6, thereby inducing myocardial hypertrophy [ 91 ]."
38490050
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"Ubiquitin-specific peptidase 10 (USP10) inhibits SIRT6 ubiquitination and degradation, reducing liver fat deposition, insulin resistance, and inflammation (94)."
37876546
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"The deubiquitination of SIRT6 by USP10 and USP48 inhibits cancer formation by preventing the growth and development of cancer cells."
37175631
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"USP10 suppresses SIRT6 ubiquitination to protect SIRT6 from proteasomal degradation."
24332849
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"USP10 also suppresses ubiquitination of the sirtuin family histone deacetylase SIRT6, leading to protection of SIRT6 from degradation by the proteasome ( Lin et al., 2013 )."
25444757
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"For instance, USP10 deubiquitinates Sirt6, which blocks AKT signaling and subsequent Ang II-induced cardiac hypertrophy."
40102846
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"In addition, Lin et al. demonstrated that USP10 enhanced the stability of SIRT6 through interacting with its N-terminal regulatory domain and deubiquitinating SIRT6, and then inhibited the transcriptional activity of the c-Myc oncogene through SIRT6 [25]."
35627217
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"USP10 deubiquitinates and stabilizes the tumor suppressor p53, and SIRT6."
27974222
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"In HCM, USP10 deubiquitinates Sirt6, which blocks AKT signaling and protects against cardiac hypertrophy [130]."
40102846
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"Additionally, USP10 can suppress SIRT6 ubiquitination, thus protecting it from proteasomal degradation, which in turn inhibits cell-cycle progression and tumor formation [219]."
40102846
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"USP10 negatively regulates SIRT6 ubiquitination."
24332849
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"By deubiquitinating Sirt6, USP10 promotes the Nrf2/ARE signaling pathway, preserves renal function, and attenuates tubular epithelial cell injury and oxidative stress in mice24."
40225869
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"USP10 deubiquitinates and stabilizes SIRT6 and helps inhibit cancer progression by antagonizing c-MYC activity[28]."
38292842
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"USP10, a ubiquitin-specific peptidase, decreases SIRT6 ubiquitination and protects SIRT6 from proteasomal degradation."
38203666
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"USP10 deubiquitinates and stabilizes SIRT6, which amplifies the tumor-suppressive activity of SIRT6."
24332849
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"Similarly, Lin et al (9) also reported that USP10, as one of the SIRT6-interacting proteins, suppresses SIRT6 ubiquitination to protect SIRT6 from proteasomal degradation."
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