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EMMAA Bob with Bioagents

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A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

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Statements

USP10 deubiquitinates SIRT6. 8 / 8

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"As previously mentioned, the peptidase USP10 de-ubiquitinates SIRT6, thereby protecting it from proteasomal degradation."

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"USP10 suppresses SIRT6 ubiquitination to protect SIRT6 from proteasomal degradation."

24332849

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"In addition, Lin et al. demonstrated that USP10 enhanced the stability of SIRT6 through interacting with its N-terminal regulatory domain and deubiquitinating SIRT6, and then inhibited the transcriptional activity of the c-Myc oncogene through SIRT6 [25]."

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"USP10 deubiquitinates and stabilizes the tumor suppressor p53, and SIRT6."

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"Review"

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"Second, USP10 suppresses SIRT6 ubiquitination and protects SIRT6 from proteasome mediated degradation."

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"USP10 deubiquitinates and stabilizes SIRT6, which amplifies the tumor-suppressive activity of SIRT6."

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"USP10 negatively regulates SIRT6 ubiquitination."

24332849

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INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...

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