IndraLab

Statements

USP10 deubiquitinates SIRT6. 8 / 8
1 | 7
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"As previously mentioned, the peptidase USP10 de-ubiquitinates SIRT6, thereby protecting it from proteasomal degradation."
| PMC
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"USP10 suppresses SIRT6 ubiquitination to protect SIRT6 from proteasomal degradation."
24332849
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"In addition, Lin et al. demonstrated that USP10 enhanced the stability of SIRT6 through interacting with its N-terminal regulatory domain and deubiquitinating SIRT6, and then inhibited the transcriptional activity of the c-Myc oncogene through SIRT6 [25]."
35627217
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"USP10 deubiquitinates and stabilizes the tumor suppressor p53, and SIRT6."
27974222
ubibrowser
"Review"
27775833
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"Second, USP10 suppresses SIRT6 ubiquitination and protects SIRT6 from proteasome mediated degradation."
24332849
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"USP10 deubiquitinates and stabilizes SIRT6, which amplifies the tumor-suppressive activity of SIRT6."
24332849
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"USP10 negatively regulates SIRT6 ubiquitination."
24332849