IndraLab

Statements

USP29 activates cell migration. 6 / 6
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"Biologically, ectopic expression of USP29 promotes gastric cancer cell migration, and depletion of Snail abolishes USP29 mediated cell migration; and USP29 can be induced by major EMT and metastatic inducing factors such as TGFbeta, TNFalpha, and hypoxia."
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"While USP29 was reported to promote gastric cancer cell migration in vitro, the exact role of USP29 in regulating gastric carcinogenesis remains unknown."
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"18 In addition, USP29 was reported to promote gastric cancer cell migration by cooperating with phosphatase SCP1 to stabilize Snail protein."
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"Deubiquitinase USP29 promotes cell migration by stabilizing Snail protein ."
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"Deubiquitinase USP29 promotes gastric cancer cell migration by cooperating with phosphatase SCP1 to stabilize Snail protein."
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"Collectively , these data indicate that Snail is a crucial substrate for USP29 to promote cell migration and USP29 / SCP1 complex may be new therapeutic targets to treat metastatic cancer ."
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