IndraLab

Statements

FN1 binds IGF1R. 9 / 9
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"Fibronectin can bind to and activate both integrin receptors and IGF-1R, thus triggering IGF-1R and phosphatidylinositol 3-kinase/protein kinase B signaling and enhancing survival of dopamine neurons."
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"A substantial proportion of IMTs displays other kinase fusions such as ROS1, PDGFRb, NTRK3, RET and FN1-IGF1R (18) ."
34211840
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"An interaction between IGF1R and fibronectin has been shown to inhibit apoptosis in pancreatic carcinoma cell lines through IGF1R transactivation [XREF_BIBR]."
21204214
sparser
"NGS may be more appealing in this scenario because can also detect other gene fusions characteristic for IMT such as PDGFR, RET, FN1–IGF1R and other rarer mutations, that may be possible targetable mutations in ALK/ROS1-negative IMTs (18, 20, 37, 38)."
34211840
sparser
"A substantial proportion of IMTs displays other kinase fusions such as ROS1, PDGFRβ, NTRK3, RET and FN1–IGF1R ( xref )."
34211840
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"Similarly, integrin β1 and the IGF-1R interactions with fibronectin mediated chemoresistance in the prostate cancer cell line DU145 xref ."
22870197
sparser
"An interaction between IGF1R and fibronectin has been shown to inhibit apoptosis in pancreatic carcinoma cell lines through IGF1R transactivation [ xref ]."
21204214
sparser
"A substantial proportion of IMTs displays other kinase fusions such as ROS1, PDGFRβ, NTRK3, RET and FN1–IGF1R (18)."
34211840
sparser
"NGS may be more appealing in this scenario because can also detect other gene fusions characteristic for IMT such as PDGFR, RET, FN1–IGF1R and other rarer mutations, that may be possible targetable mutations in ALK/ROS1-negative IMTs ( xref , xref , xref , xref )."
34211840