IndraLab

Statements

FN1 binds IGF1R. 10 / 10
| 2 8
sparser
"An interaction between IGF1R and fibronectin has been shown to inhibit apoptosis in pancreatic carcinoma cell lines through IGF1R transactivation [ xref ]."
21204214
sparser
"Similarly, integrin β1 and the IGF-1R interactions with fibronectin mediated chemoresistance in the prostate cancer cell line DU145 xref ."
22870197
sparser
"It should be noted, however, that while the predicted protein product of IGF1R‐TTC23 seems not to carry any enzymatic activities, FN1‐IGF1R should retain the intracellular tyrosine kinase domain of IGF1R."
31222839
sparser
"NGS may be more appealing in this scenario because it can also detect other gene fusions characteristic for IMT, such as PDGFR, RET, FN1–IGF1R, and other rarer mutations targetable in ALK/ROS1-negative IMTs."
37051474
reach
"Fibronectin can bind to and activate both integrin receptors and IGF-1R, thus triggering IGF-1R and phosphatidylinositol 3-kinase/protein kinase B signaling and enhancing survival of dopamine neurons."
25206678
sparser
"Piarulli et al xref reported on a patient with an ALK‐negative inflammatory myofibroblastic tumor carrying FN1‐IGF1R fusion transcript."
31222839
reach
"An interaction between IGF1R and fibronectin has been shown to inhibit apoptosis in pancreatic carcinoma cell lines through IGF1R transactivation [XREF_BIBR]."
21204214
sparser
"A substantial proportion of IMTs displays other kinase fusions such as ROS1, PDGFRβ, NTRK3, RET and FN1–IGF1R ( xref )."
34211840
sparser
"NGS may be more appealing in this scenario because can also detect other gene fusions characteristic for IMT such as PDGFR, RET, FN1–IGF1R and other rarer mutations, that may be possible targetable mutations in ALK/ROS1-negative IMTs ( xref , xref , xref , xref )."
34211840
sparser
"In this work, we showed for the first time that the highly expressed hemocyte protein Sb IGF-1R could bind with Sb Fn, providing an anchoring site for ferritin on the cell surface."
37047145