IndraLab

Statements

USP6 inhibits Neoplasms. 5 / 5
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"In sum, these results indicate that USP6 is sufficient to drive intratumoral activation of NK cells in Ewing sarcoma in vivo, and that NK cells are required for suppression of tumor growth by USP6."
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"Here, we demonstrate an essential role for NK cells in USP6-mediated tumor suppression."
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"Strikingly, we observed that USP6 inhibited growth of Ewing sarcoma tumors when xenografted into nude but not NOD scid gamma (NSG) mice, implicating a role for the innate immune system in mediating the tumor-suppressive function of USP6 (20)."
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"NK Cells are Required for Suppression of Ewing Sarcoma Tumor Growth by USP6."
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"We previously demonstrated that USP6 inhibits growth of Ewing sarcoma tumors when xenografted into nude mice, but not NSG mice (20)."
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