IndraLab

Statements

KCNH2 activates VEGF. 4 / 4
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"In addition, we present evidence that, in GBM cell lines, hERG1 channel activity actively contributes to malignancy by promoting vascular endothelial growth factor secretion, thus stimulating the neoangiogenesis typical of high-grade gliomas."
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"HERG1 can increase oncogenic potential in leukemias by affecting one of several ways facilitating leukemogenesis : (1) balance between proliferation and cell death; (2) invasiveness, depending on the fine balance between adhesion and motility, the latter being in turn dependent on polarized volume changes; (3) resistance to chemotherapy [XREF_BIBR, XREF_BIBR]; (4) angiogenesis, via secretion of vascular endothelial growth factor (VEGF) and positively feedbacked microvesicles release [XREF_BIBR, XREF_BIBR]."
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"For instance, in human acute myeloid leukemia cells, hERG1 channels appear to mediate the vascular endothelial growth factor receptor-1-dependent cell migration and invasion, both in vitro and in vivo."
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"HERG1 channels are overexpressed in glioblastoma multiforme and modulate VEGF secretion in glioblastoma cell lines."
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