IndraLab

Statements

USP7 binds USP47. 7 / 7
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"Given the association of USP7 and USP47 with the MDM2-p53 pathway xref , xref , we investigated whether the impact of USP7 and USP47 on cancer cell growth is dependent on p53."
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"Furthermore, activated inflammasomes also regulate USP7 and USP47 activity, which forms a positive feedback pathway for resistance to pathogen infection ( xref )."
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"This study showed that chemical inhibition of USP7 and USP47 blocked inflammasome formation and that although both DUBs contributed to inflammasome activation, its activation was majorly impaired when both USP7 and USP47 were not present."
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"However, the biggest potential limitation that emerges from this paper is that all of the known USP7 inhibitors (until recently) also interact with USP47 ( Altun et al., 2011 )."
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"P22077, a USP7 inhibitor, has also been shown to inhibit the NF-κB and MAPKs pathways and exert important anti-inflammatory effects in vitro and in vivo by promoting K48-linked ubiquitination and TRAF6 degradation. xref Palazon-Riquelme et al xref found that in macrophages, P22077 prevents the formation and activation of inflammatory vesicles by inhibiting USP7 and USP47 and reducing ASC oligomerization and speckling."
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"Whether USP7 and USP47 directly interact with NLRP3 receptor or with other inflammasome component was not investigated."
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"However, there is no evidence of direct interaction between USP7, USP47, and NLRP3 [XREF_BIBR]."
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