IndraLab

Statements

CAST activates mutated ATXN3. 2 / 2
| 2
reach
"Oral administration of the calpain inhibitor BDA-410 to the SCA3 mouse model reduced the toxic fragments of the mutant ATXN3 protein, decreased the number of its inclusions, and prevented cerebellar cell loss, suggesting that calpain inhibitors may mediate neuroprotection and inhibit proteolysis (Simões et al., 2014)."
38894941
reach
"Calpastatin, a calpain inhibitor, decreases the nuclear uptake and aggregation of mutant ATXN3, delaying neurodegeneration in SCA3 mouse models."
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