IndraLab

Statements

E2F4 binds USP2. 14 / 14
6 | 2 6
sparser
"Emetine, an autophagy inhibitor, can block the interaction between USP2 and E2F4 and promote E2F4 degradation for an oncogenic effect, which can be reversed upon USP2 overexpression ( xref )."
37594087
sparser
"In clinical gastric cancer specimens, both USP2 and E2F4 were upregulated and associated with poor outcome of patients."
35253629
biogrid
No evidence text available
35253629
sparser
"These findings indicate that therapeutic targeting of the USP2-E2F4 axis inhibits autophagic machinery essential for zinc homeostasis in cancer progression."
35253629
biogrid
No evidence text available
35253629
sparser
"By blocking the USP2-E2F4 interaction, emetine inhibited autophagy and GC aggressiveness, suggesting the therapeutic potential of targeting the USP2-E2F4 axis [ xref ]."
36497313
biogrid
No evidence text available
35253629
biogrid
No evidence text available
35253629
sparser
"It has been reported that E2F4 binds directly with USP2 (ubiquitin specific peptidase 2) in gastric cancer cells [ xref ], while USP2 could bind with SKP2 and USP2-stabilized SKP2 did not destabilize its substrate P21 [ xref ]."
38980592
biogrid
No evidence text available
35253629
sparser
"Therapeutic targeting of the USP2-E2F4 axis inhibits autophagic machinery essential for zinc homeostasis in cancer progression."
35253629
biogrid
No evidence text available
35253629
reach
"It has been reported that E2F4 binds directly with USP2 (ubiquitin specific peptidase 2) in gastric cancer cells [29], while USP2 could bind with SKP2 and USP2-stabilized SKP2 did not destabilize its substrate P21 [30]."
38980592
reach
"Based on a combination of these reports we hypothesized that DAPL1 regulation of P21 ubiquitination might partially be through interaction with the E2F4/USP2 complex.CD8 + T cells play critical roles in the immune response against infections and cancer."
38980592