IndraLab

Statements

SPOP binds USP2. 5 / 5
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"Moreover, we demonstrated that SPOP interacts with USP2, promoting its ubiquitination and subsequent degradation, which in turn facilitates CD47 degradation ( xref xref )."
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"Notably, deletion of degron 2 in USP2, but not degron 1, could reduce the interaction between SPOP and USP2 in this experimental setting ( xref )."
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"Consistent with the fact that the N-terminal MATH (meprin and TRAF-C homology) domain of SPOP recognizes substrates, xref we found that deletion of the MATH domain eliminated SPOP binding to USP2."
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"Depletion of the BTB domain, which was previously reported to largely mediate the interaction with the cullin 3 complex, xref did not affect SPOP binding to USP2 ( xref )."
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"In further support of degron 2 as the critical motif recognized by SPOP, mutation of degron 2 also decreased the interaction between SPOP and USP2 ( xref )."
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