IndraLab

Statements

TNF activates KCNA3. 2 / 2
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reach
"Following peripheral administration in a mouse model of neuroinflammation induced by LPS, HsTX1[R14A] readily crosses the blood–brain barrier (BBB) [24] to achieve microglial Kv1.3 blockade, with a substantial reduction in plasma and brain levels of cytokines, including TNF-α, interleukin 1β (IL-1β) and interleukin-6 (IL-6) [23, 25]."
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sparser
"Tumor necrosis factor-alpha-induced activation of macrophages increased Kv1.3 with no changes in Kv."
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