IndraLab

Statements

COPS5 inhibits NFkappaB. 6 / 8
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"Further, siRNA mediated repression of CSN5, a subunit of the COP9 signalosome responsible for deneddylation of Cul-1, partially reversed HPC mediated inhibition of NF-kappaB."
17318263
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"JAB1 silence induced Ik-Balpha degradation, enhanced NF-kappaB activity, increased the TNF-a-induced expression of adhesion molecules (CCL2, ICAM-1, VCAM-1) and induced monocytes arrest rate on inflamed endothelium in vitro [XREF_BIBR]."
28173800
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"The work of others has demonstrated that CSN5 is a negative regulator of NF-kappaB and a decrease in CSN5 increases nuclear NF-kappaB thereby stimulating proliferation."
28623958
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"Gene suppression of the CSN subunit JAB1 and Csn5 augmented constitutive NF-kappaB activity, while ectopic expression of JAB1 reduced it."
19656241
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"Furthermore, CSN5 silencing enhanced TNF-alpha-induced IkappaB-alpha degradation and NF-kappaB activity in luciferase reporter assays."
23636414
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"This notion was supported by reporter gene assays for NF-kappaB activity, which revealed that ectopic expression of JAB1 significantly reduces basal NF-kappaB activity, while suppression of endogenous JAB1 by RNA interference leads to a prominent up-regulation (XREF_FIG)."
19656241