IndraLab

Statements

USP47 activates NLRP3. 8 / 8
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"The DUBs USP7 and USP47 activate the NLRP3 inflammasome, but the specific mechanism is not clear (Palazón-Riquelme et al., 2018)."
36688154
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"In addition, inhibition of USP7 and USP47 blocks the NLRP3 inflammasome by preventing apeck-like protein containing a CARD (ASC) oligomerization and speck formation in macrophages [38]."
32650621
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"Inhibition of USP7 and USP47 impairs NLRP3 inflammasome activation in macrophages."
30206189
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"USP7 and USP47 also promote NLRP3 activation [55]."
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"For example, USP7 and USP47 promote the NLRP3 inflammasome by accelerating an apeck-like protein containing a CARD (ASC) oligomerization in macrophages [49]."
40108019
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"It is then possible that this process is regulated by K11 linked ubiquitin chains, yet it is also possible that USP7 and USP47 do not directly target NLRP3 and that an additional regulated protein, upstream of this process, is mediating this effect."
30206189
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"USP47 inhibition alleviated cardiac functions, and decreased infarct size, pro-inflammatory cytokines, NETs, NLRP3, and pyroptosis."
38850785
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"Moreover, USP7, USP47, and BRCC3 and ABRO can activate the NLRP3 inflammasome."
32850399