IndraLab

Statements

USP47 activates NLRP3. 4 / 4
| 4
reach
"Inhibition of USP7 and USP47 impairs NLRP3 inflammasome activation in macrophages."
30206189
reach
"In addition, inhibition of USP7 and USP47 blocks the NLRP3 inflammasome by preventing apeck-like protein containing a CARD (ASC) oligomerization and speck formation in macrophages [38]."
32650621
reach
"Moreover, USP7, USP47, and BRCC3 and ABRO can activate the NLRP3 inflammasome."
32850399
reach
"It is then possible that this process is regulated by K11 linked ubiquitin chains, yet it is also possible that USP7 and USP47 do not directly target NLRP3 and that an additional regulated protein, upstream of this process, is mediating this effect."
30206189