IndraLab

Statements

OTUD3 inhibits apoptotic process. 6 / 6
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"However, in lung cancer, OTUD3 promotes tumour proliferation and metastasis and inhibits apoptosis through deubiquitination of GRP78 protein and is closely related to drug resistance (163)."
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"Downregulation of OTUD3 reduced the binding ability of Fortilin to IRE1α, thereby activating the IRE1α pathway and inducing ER stress and neuronal apoptosis."
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"The deubiquitinase OTUD3 has been shown to mediate endoplasmic reticulum stress to inhibit dopaminergic neuronal apoptosis by regulating Fortilin stability [28]."
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"In the present study, our results demonstrated that OTUD3 knockdown-induced ER stress and cell apoptosis through the activation of the IRE1α pathway but not the PERK or ATF6α pathways."
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"Reversal of OTUD3 protein expression or treatment with IRE1α inhibitor STF-083010 could ameliorate IRE1α signal activation and inhibit apoptosis."
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"OTUD3 regulates the level of fortilin ubiquitination, affects endoplasmic reticulum stress, and inhibits dopaminergic neuronal apoptosis (Chen et al., 2023)."
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