IndraLab

Statements

USP8 activates Neoplasm Invasiveness. 3 / 3
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"USP8 inhibition in combination with PD-1/PD-L1 blockade increased CD8 T cell infiltration and diminished tumor growth, compared to immune checkpoint blockade monotherapy."
38915093
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"Notably, USP8 inhibition in combination with ferroptosis inducers suppresses the tumor growth and promotes CD8 T cell infiltration in the tumor microenvironment, which sets up a situation that makes the PD-1/PD-L1 blockade more effective in vivo."
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"These data together suggest that USP8 inhibition by its pharmacologic inhibitor or genetic deletion in combination with SAS treatment effectively suppresses tumor growth and enhances CD8 T cell infiltration in tumors."
38598341