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PSMD14 inhibits apoptotic process. 27 / 27
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"PSMD14 knockdown also promoted cell apoptosis by increasing cleaved caspase-3 levels in H1299 cells."
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"More importantly, cytoplasm restricted expression of POH1 did not alleviate the inhibition of cell growth and the induction of cell apoptosis caused by endogenous POH1 deletion (XREF_FIG and XREF_SUPPLEMENTARY)."
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"To determine the mechanism underlying apoptosis mediated by POH1 knockdown, we examined whether the intrinsic apoptosis was involved in this process."
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"We studied the oncogenic function of POH1 in solid tumors; knockdown of POH1 expression in QGY-7701, EC109, and HCT116 cells decreased cell viability and induced apoptosis."
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"Furthermore , the knockdown of POH1 inhibited tumor progression and induced apoptosis in mitochondria in vitro and RNAi of POH1 achieved similar results in vivo [ 173 ] ."
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"POH1 knockdown induced HCC cell apoptosis."
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"JC-1 staining showed that POH1 knockdown increased the red-to-green fluorescence intensity ratio, indicative of the damage of the mitochondrial transmembrane potential -- one of the signatures of apoptosis mediated by the mitochondrial pathway (XREF_FIG E)."
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"Our results imply that PSMD14 knockdown induced osteosarcoma cell apoptosis and inhibited in vitro cell proliferation.Using transwell assays, we subsequently investigated the impact of PSMD14 knockdown on osteosarcoma cell motility."
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"Similarly, PSMD14 knockdown led to apoptosis in both KYSE 30 and KYSE 150 cells (XREF_SUPPLEMENTARY)."
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"And PSMD14 inhibition can induce multiple myeloma cell apoptosis and overcome bortezomib resistance (Song et al., 2017)."
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"Then, we discovered that PSMD14 could boost the proliferation, invasion, and migration of drug-resistant strains and block the apoptosis of drug-resistant strains."
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"Here, we show that the silencing and pharmacological blockade of PSMD14 in MDA-MB 435S breast cancer cells induce paraptosis, a non-apoptotic cell death mode characterized by extensive vacuolation derived from the endoplasmic reticulum (ER) and mitochondria."
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"Recent studies have suggested that knockdown of POH1 may induce cancer cell apoptosis XREF_BIBR, XREF_BIBR."
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"Taken together, POH1 knockdown may induce apoptosis mediated via mitochondrial pathway."
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"The knockdown of POH1 significantly inhibited tumor cell proliferation and induced apoptosis mediated by the mitochondrial pathway in vitro."
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"Flow cytometry results revealed that PSMD14 knockdown significantly induced cell apoptosis, with the highest apoptotic rate observed in PSMD14 knockdown + cisplatin treatment group (Fig. 3B)."
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"Rpn11 is responsible for deubiquitinylation of proteasomal substrates (Verma et al., 2002) Inhibition of Rpn11 has been reported to overcome bortezomib resistance and induce apoptosis in multiple myeloma cells (Song et al., 2017)."
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"PSMD14 knockdown induces cell cycle arrest , senescence and apoptosis by regulating cell cycle proteins in H1299 cells 30 ."
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"In line with this, knockdown of two components of the UPS, the ubiquitin ligase scaffolding protein Cul-1 and the proteasome-associated deubiquitinating protein Pad-1, leads to cell cycle reactivation and apoptosis in subsets of post-mitotic neurons (Staropoli and Abeliovich 2005)."
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"In addition, our data showed POH1 knockdown induced higher apoptosis in HCT116 p53 +/+ cells as compared with HCT116 p53 -/- cells."
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"We investigate the clinicopathological relevance of the epigenetic coordination between PSMD14 and NSD2 and the therapeutic potential of pharmacological inhibition of PSMD14 in the treatment of MM.It [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Overall, POH1 knockdown induced cell apoptosis through increased expression of p53 and Bim via enhanced protein stability and attenuated degradation."
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"Pharmacological inhibition of PSMD14(Rpn11) with O-phenanthroline (OPA) blocks cellular proteasome function, induces apoptosis in MM cells, and overcomes resistance to proteasome inhibitor bortezomib [26]."
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"PSMD14 knockdown induces cell cycle arrest, senescence and apoptosis by regulating cell cycle proteins in H1299 cells XREF_BIBR."
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"Furthermore, we observed that POH1 silencing induced cell apoptosis through an increase in the expression of p53 and Bim mediated by enhanced protein stability."
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"Consistently, immunostaining of harvested tumors showed that PSMD14 knockdown was associated with a decreased cell proliferation, as indicated by Ki-67 staining, and an increased number of apoptotic c[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Moreover, flow cytometry by annexin V-APC/PI double staining showed that PSMD14 inhibitions led to an increased apoptosis of both LP-1 and LP-1 BR cells ( Figure 6 B)."
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