IndraLab

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PSMD14 inhibits apoptotic process. 19 / 19
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"Taken together, POH1 knockdown may induce apoptosis mediated via mitochondrial pathway."
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"Similarly, PSMD14 knockdown led to apoptosis in both KYSE 30 and KYSE 150 cells (XREF_SUPPLEMENTARY)."
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"Rpn11 is responsible for deubiquitinylation of proteasomal substrates (Verma et al., 2002) Inhibition of Rpn11 has been reported to overcome bortezomib resistance and induce apoptosis in multiple myeloma cells (Song et al., 2017)."
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"Overall, POH1 knockdown induced cell apoptosis through increased expression of p53 and Bim via enhanced protein stability and attenuated degradation."
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"Here, we show that the silencing and pharmacological blockade of PSMD14 in MDA-MB 435S breast cancer cells induce paraptosis, a non-apoptotic cell death mode characterized by extensive vacuolation derived from the endoplasmic reticulum (ER) and mitochondria."
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"Furthermore, the knockdown of POH1 inhibited tumor progression and induced apoptosis in mitochondria in vitro and RNAi of POH1 achieved similar results in vivo [173]."
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"JC-1 staining showed that POH1 knockdown increased the red-to-green fluorescence intensity ratio, indicative of the damage of the mitochondrial transmembrane potential -- one of the signatures of apoptosis mediated by the mitochondrial pathway (XREF_FIG E)."
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"Recent studies have suggested that knockdown of POH1 may induce cancer cell apoptosis XREF_BIBR, XREF_BIBR."
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"To determine the mechanism underlying apoptosis mediated by POH1 knockdown, we examined whether the intrinsic apoptosis was involved in this process."
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"We studied the oncogenic function of POH1 in solid tumors; knockdown of POH1 expression in QGY-7701, EC109, and HCT116 cells decreased cell viability and induced apoptosis."
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"In addition, our data showed POH1 knockdown induced higher apoptosis in HCT116 p53 +/+ cells as compared with HCT116 p53 -/- cells."
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"PSMD14 knockdown induces cell cycle arrest, senescence and apoptosis by regulating cell cycle proteins in H1299 cells XREF_BIBR."
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"PSMD14 knockdown also promoted cell apoptosis by increasing cleaved caspase-3 levels in H1299 cells."
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"PSMD14 knockdown induces cell cycle arrest , senescence and apoptosis by regulating cell cycle proteins in H1299 cells 30 ."
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"POH1 knockdown induced HCC cell apoptosis."
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"Furthermore, we observed that POH1 silencing induced cell apoptosis through an increase in the expression of p53 and Bim mediated by enhanced protein stability."
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"More importantly, cytoplasm restricted expression of POH1 did not alleviate the inhibition of cell growth and the induction of cell apoptosis caused by endogenous POH1 deletion (XREF_FIG and XREF_SUPPLEMENTARY)."
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"Furthermore , the knockdown of POH1 inhibited tumor progression and induced apoptosis in mitochondria in vitro and RNAi of POH1 achieved similar results in vivo [ 173 ] ."
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"The knockdown of POH1 significantly inhibited tumor cell proliferation and induced apoptosis mediated by the mitochondrial pathway in vitro."
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