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This Service

A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

ARNTL activates USP2. 2 / 2

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"The circadian rhythm of Usp2 is blunted in Clock mutant and Bmal1 KO mice, and the Usp2 promoter is activated by CLOCK and BMAL1, indicating that Usp2 is a direct target of these transcription factors."

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"This suggests a scenario in USP2 -/- mice in which increased turnover of BMAL1 coincides with increased CLOCK and BMAL1 driven gene expression in the USP2 -/- SCN."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...