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USP15 activates YAP1. 12 / 12
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"Ubiquitin-specific protease 15 (USP15) was reported to promote pulmonary vascular remodeling in PAH by stabilizing YAP1 through the inhibition of the K48-linked ubiquitination of YAP1 ( Table 1 ) [ 16[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"USP15 deficiency inhibited cell proliferation, migration, and YAP1/TAZ signaling in hypoxia-induced hPASMCs."
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"Thus, we propose that USP15 might be a novel regulator of YAP1/TAZ signaling during PH progression.Our rescue assay determined that USP15 promoted the proliferation and migration of hypoxia-exposed PASMCs in a YAP1/TAZ-dependent manner."
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"USP15 overexpression promoted hPASMC proliferation and migration in a YAP1/TAZ-dependent manner."
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"USP15 promotes pulmonary vascular remodeling in pulmonary hypertension in a YAP1/TAZ-dependent manner."
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"To further explore whether USP15 mediated hPASMC proliferation and migration in a YAP1/TAZ-dependent manner, we achieved the depletion of YAP1 or TAZ in USP15-overexpressing hPASMCs by corresponding adenovirus infection."
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"We, therefore, explored whether USP15 contributes to PH development by deubiquitinating YAP1 and found that USP15 promoted the stability of YAP1 by inhibiting K48-linked ubiquitination of YAP1."
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"USP15 promoted YAP1 stability by inhibiting K48-linked ubiquitination of YAP1."
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"Human pulmonary artery smooth muscle cells (hPASMCs) were exposed to hypoxia to mimic PH in vitro, and USP15 knockdown significantly inhibited cell proliferation, migration, and YAP1/TAZ signaling in hypoxic hPASMCs."
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"The CHX chase assay further determined that USP15 promoted the protein stability of YAP1 in normoxic hPASMCs (Fig. 8f)."
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"Rescue assays further suggested that USP15 promoted hPASMC proliferation and migration in a YAP1/TAZ-dependent manner."
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"Taken together, our findings indicate that USP15 might promote PH progression in a YAP1/TAZ-dependent manner (Supplementary Fig. 3)."
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