IndraLab

Statements

AZA-2 inhibits KCNH2. 2 / 2
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"The IC 50 reported by Twiner et al. for AZA-2 blockade of hERG was 0.64 muM (moderate blockers IC 50 : 0.1-1 muM)."
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"In summary, AZA-2 blocks the hERG cardiac potassium channel in vitro and, although no QT c interval prolongation is observed in vivo, AZA-2 clearly causes prolongation of PR interval and the appearance of arrhythmias in rat ECGs, indicating an alteration of heart electrophysiology in vivo."
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